abstract：PURPOSE:Sexual dysfunction is reported in women with breast cancer (BC). It is unclear whether symptoms persist over time as data comparing long-term survivors to controls are lacking. We compared sexual functioning in long-term breast cancer survivors (BCS) to controls and determined the impact of adjuvant therapy on ...

journal_title：Breast cancer research and treatment

authors： Soldera SV,Ennis M,Lohmann AE,Goodwin PJ

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Mobile mammography can improve access to screening mammography in rural areas and underserved populations. We evaluated the frequency of incomplete reports in mobile mammography screening and the relationships between prior mammograms and recall rates. METHODS:The frequency of incomplete mammogram reports, the...

journal_title：Breast cancer research and treatment

authors： Roubidoux MA,Shih-Pei Wu P,Nolte ELR,Begay JA,Joe AI

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast...

journal_title：Breast cancer research and treatment

authors： O'Loughlin M,Andreu X,Bianchi S,Chemielik E,Cordoba A,Cserni G,Figueiredo P,Floris G,Foschini MP,Heikkilä P,Kulka J,Liepniece-Karele I,Regitnig P,Reiner A,Ryska A,Sapino A,Shalaby A,Stovgaard ES,Quinn C,Walsh EM,Z

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:As the number of survivors continues to increase with improvements in breast cancer treatment, greater emphasis has been placed on the aesthetic outcome following breast surgery. Effort is made to minimize scarring on the breast, yet patients who require a port for treatment inevitably have a scar on the upper ...

journal_title：Breast cancer research and treatment

authors： Voci A,Lee D,Ho E,Crane-Okada R,DiNome M

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of w...

journal_title：Breast cancer research and treatment

authors： Wadsten C,Wennstig AK,Garmo H,Nilsson G,Blomqvist C,Holmberg L,Fredriksson I,Wärnberg F,Sund M

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhi...

journal_title：Breast cancer research and treatment

authors： O'Shaughnessy J,DeMichele A,Ma CX,Richards P,Yardley DA,Wright GS,Kalinsky K,Steis R,Diab S,Kennealey G,Geschwindt R,Jiang W,Rugo HS

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:We have reported a survival benefit of single injection of hydroxyprogesterone prior to surgery for primary tumour in patients with node-positive operable breast cancer. Hydroxyprogesterone was meant to recapitulate the luteal phase of menstrual cycle in these women. We wanted to understand the molecular basis ...

journal_title：Breast cancer research and treatment

authors： Chatterjee S,Chaubal R,Maitra A,Gardi N,Dutt A,Gupta S,Badwe RA,Majumder PP,Pandey P

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:The purpose of the study was to assess self-reported taste and smell perception after chemotherapy in breast cancer patients compared with women without cancer, and to assess whether taste and smell perception is associated with quality of life after the end of chemotherapy. METHODS:We included 135 newly diagn...

journal_title：Breast cancer research and treatment

authors： de Vries YC,Boesveldt S,Kelfkens CS,Posthuma EE,van den Berg MMGA,de Kruif JTCM,Haringhuizen A,Sommeijer DW,Buist N,Grosfeld S,de Graaf C,van Laarhoven HWM,Kampman E,Winkels RM

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Radial scar's stellate appearance may mimic carcinoma mammographically and histologically. Management of radial scar (RS) found on breast core needle biopsies (CNB) ranges from excision to clinical observation due to the variation in reported upgrades to malignancy at surgical excision. We examined the upgrade ...

journal_title：Breast cancer research and treatment

authors： Chou WYY,Veis DJ,Aft R

更新日期：2018-07-01 00:00:00

abstract：:The third category for extent of involution in Table 4 was published incorrectly in the original publication. The correct classification is ≥ 75% and the corrected Table 4 is given in the Correction article. ...

journal_title：Breast cancer research and treatment

authors： Arthur R,Wang Y,Ye K,Glass AG,Ginsberg M,Loudig O,Rohan T

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Younger women diagnosed with breast cancer have poorer prognoses and higher mortality compared to older women. Young black women have higher incidence rates of breast cancer and more aggressive subtypes than women of other races/ethnicities. In this study, we examined recent trends and variations in breast canc...

journal_title：Breast cancer research and treatment

authors： Shoemaker ML,White MC,Wu M,Weir HK,Romieu I

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The objective of this study is to understand an impact of financial burden on the adjuvant hormonal therapy (AHT) adherence and persistence for insured women aged 18-64 with early breast cancer in Texas. METHODS:We conducted a retrospective cohort study using claims data for population insured by Blue Cross Bl...

journal_title：Breast cancer research and treatment

authors： Kim J,Rajan SS,Du XL,Franzini L,Giordano SH,Morgan RO

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The Ki67 proliferation index is a prognostic and predictive marker in breast cancer. Manual scoring is prone to inter- and intra-observer variability. The aims of this study were to clinically validate digital image analysis (DIA) of Ki67 using virtual dual staining (VDS) on whole tissue sections and to assess ...

journal_title：Breast cancer research and treatment

authors： Koopman T,Buikema HJ,Hollema H,de Bock GH,van der Vegt B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Despite numerous studies on the utility of GATA-3 as breast cancer marker, its comparison with other breast markers, its concordance between primary and metastatic tumors and its expression in primary cancers from sites with frequent breast metastases remains unclear. METHODS:To address these questions, totall...

journal_title：Breast cancer research and treatment

authors： Ni YB,Tsang JYS,Shao MM,Chan SK,Cheung SY,Tong J,To KF,Tse GM

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Although quality of life (QoL) improves over time for most breast cancer survivors (BCS), BCS may show different patterns of QoL. This study sought to identify distinct QoL trajectories among BCS and to examine characteristics associated with trajectory group membership. METHODS:BCS (N = 653) completed baselin...

journal_title：Breast cancer research and treatment

authors： Goyal NG,Levine BJ,Van Zee KJ,Naftalis E,Avis NE

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Germline mutations in BRCA1 and BRCA2 confer a significant increase in risk for cancer, and determining pathogenicity of a BRCA variant can guide the clinical management of the disease. About 1/3 of BRCA1 variants reported in the public databases have uncertain clinical significance due to lack of conclusive ev...

journal_title：Breast cancer research and treatment

authors： Yang C,Jairam S,Amoroso KA,Robson ME,Walsh MF,Zhang L

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Breast tumors from young women under the age of 40 account for approximately 7% of cases and have a poor prognosis independent of established prognostic factors. We evaluated the patient population served by the Military Health System, where a disproportionate number of breast cancer cases in young women are se...

journal_title：Breast cancer research and treatment

authors： Zimmer AS,Zhu K,Steeg PS,Wu A,Gatti-Mays ME,Soltani S,Perkins JG,Shao S,Brown D,Georg M,Hu H,Shriver CD,Lipkowitz S

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. METHODS:This cross-sectional study included 192 CA and 173 NHW female bre...

journal_title：Breast cancer research and treatment

authors： Nomura SJO,Hwang YT,Gomez SL,Fung TT,Yeh SL,Dash C,Allen L,Philips S,Hilakivi-Clarke L,Zheng YL,Wang JH

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:To validate the newly proposed American Joint Committee on Cancer (AJCC) prognostic staging system for breast cancer. METHODS:Surveillance, epidemiology, and end results (SEER) database (2010-2014) was accessed. Cumulative incidence function was conducted (through assessment of sub-distribution hazard) acco...

journal_title：Breast cancer research and treatment

authors： Abdel-Rahman O

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Body composition parameters including low muscle mass, muscle attenuation (which reflects muscle quality) and adipose tissue measurements have emerged as prognostic factors in cancer patients. However, knowledge regarding the possibility of excessive muscle loss during specific systemic therapies is unknown. We...

journal_title：Breast cancer research and treatment

authors： Rier HN,Jager A,Sleijfer S,van Rosmalen J,Kock MCJM,Levin MD

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast cancer diagnosis, or the probability of being diagnosed with ...

journal_title：Breast cancer research and treatment

authors： Brouckaert O,Van Asten K,Laenen A,Soubry A,Smeets A,Nevelstreen I,Vergote I,Wildiers H,Paridaens R,Van Limbergen E,Weltens C,Moerman P,Floris G,Neven P,Multidisciplinary breast centre Leuven.

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To examine DNA methylation as a mechanism linking diet, physical activity, weight status, and breast cancer risk. METHODS:Insufficiently active women of varying weight status, without a history of cancer, completed a maximal exercise test, clinical measurement of height and weight, and a dietary intake measure...

journal_title：Breast cancer research and treatment

authors： Gillman AS,Gardiner CK,Koljack CE,Bryan AD

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:The American Society of Clinical Oncology recommends concurrent palliative care (PC) for patients with metastatic cancer. Recent data show benefits of early PC (at least 90 days before death). However, little is known about PC among patients who die from metastatic breast cancer. METHODS:Patients with metastat...

journal_title：Breast cancer research and treatment

authors： Rabow M,Small R,Jow A,Majure M,Chien A,Melisko M,Belkora J,Esserman LJ,Rugo H

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To evaluate a simplified method of pre-test information and germline BRCA1/2 mutation testing. METHODS:In a prospective, single-arm study, comprehensive BRCA1/2 testing was offered to unselected patients with newly diagnosed breast cancer at three hospitals in south Sweden (BRCAsearch, ClinicalTrials.gov Ident...

journal_title：Breast cancer research and treatment

authors： Nilsson MP,Törngren T,Henriksson K,Kristoffersson U,Kvist A,Silfverberg B,Borg Å,Loman N

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:In rodents, a single exercise bout performed 24 h prior to a single doxorubicin treatment provides cardio-protection. This study investigated whether performing this intervention prior to every doxorubicin treatment for breast cancer reduced subclinical cardiotoxicity and treatment symptoms. METHODS:Twenty-fou...

journal_title：Breast cancer research and treatment

authors： Kirkham AA,Eves ND,Shave RE,Bland KA,Bovard J,Gelmon KA,Virani SA,McKenzie DC,Stöhr EJ,Waburton DER,Campbell KL

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Differences in de novo (dnMBC) and recurrent metastatic breast cancer (rMBC) presentation and survival over time have not been adequately described. METHODS:A retrospective cohort study, 1990-2010, with follow up through 2015 of dnMBC patients (stage IV at diagnosis) and rMBC patients with subsequent distan...

journal_title：Breast cancer research and treatment

authors： Malmgren JA,Mayer M,Atwood MK,Kaplan HG

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To evaluate the association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer (BC) risk. METHODS:A cohort of all Maccabi Healthcare Services (MHS) female members aged 40-50 years between 1/2003 and 12/2013 was used to identify LNG-IUS users as "cases," and 2 age-matched non-u...

journal_title：Breast cancer research and treatment

authors： Siegelmann-Danieli N,Katzir I,Landes JV,Segal Y,Bachar R,Rabinovich HR,Bialik M,Azuri J,Porath A,Lomnicky Y

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:This study investigates weight trajectories in pre- versus postmenopausal breast cancer (BC) survivors diagnosed with hormone receptor-positive tumors, with a specific focus on discerning menopausal status and type of endocrine treatment (ET) as risk factors for weight gain during ET. METHODS:We conducted a re...

journal_title：Breast cancer research and treatment

authors： Nyrop KA,Deal AM,Lee JT,Muss HB,Choi SK,Wheless A,Carey LA,Shachar SS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Given its high recurrence risk, guidelines recommend systemic therapy for most patients with early-stage triple-negative breast cancer (TNBC). While some clinicopathologic factors and tumor-infiltrating lymphocytes (TILs) are known to be prognostic in patients receiving chemotherapy, their prognostic implica...

journal_title：Breast cancer research and treatment

authors： Leon-Ferre RA,Polley MY,Liu H,Gilbert JA,Cafourek V,Hillman DW,Elkhanany A,Akinhanmi M,Lilyquist J,Thomas A,Negron V,Boughey JC,Liu MC,Ingle JN,Kalari KR,Couch FJ,Visscher DW,Goetz MP

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Nearly half of the 3.5 million female breast cancer survivors in the US are aged 65 years or older at diagnosis, yet little is known about associations of obesity and physical activity with breast cancer-specific mortality (BCSM) among older survivors. METHODS:Between 1992 and 2013, 5254 women in the Cancer Pr...

journal_title：Breast cancer research and treatment

authors： Maliniak ML,Patel AV,McCullough ML,Campbell PT,Leach CR,Gapstur SM,Gaudet MM

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:The present study evaluated whether morphological-measured stromal and intra-tumour tumour-infiltrating lymphocytes (TILs) levels were associated with gene expression profiles, and whether TILs-associated genomic signature (GS) could be used to predict clinical outcomes and response to therapies in several brea...

journal_title：Breast cancer research and treatment

authors： Kochi M,Iwamoto T,Niikura N,Bianchini G,Masuda S,Mizoo T,Nogami T,Shien T,Motoki T,Taira N,Tokuda Y,Doihara H,Matsuoka J,Fujiwara T

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Platelets are essential components of hemostasis and also play an important role in the tumor microenvironment. The purposes of our research were to examine the role of thrombocytosis in inflammatory breast cancer (IBC) and to know which cytokine drives thrombocytosis. METHODS:We reviewed the medical records o...

journal_title：Breast cancer research and treatment

authors： Harano K,Kogawa T,Wu J,Yuan Y,Cohen EN,Lim B,Reuben JM,Ueno NT

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:We investigated the associations of adolescent adiposity, changes in adiposity during adulthood, and attained adiposity with volumetric mammographic density measures. METHODS:We recruited 383 premenopausal women who had a routine screening mammogram at the Breast Health Center, Washington University in St. Lou...

journal_title：Breast cancer research and treatment

authors： Alimujiang A,Appleton C,Colditz GA,Toriola AT

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:A number of studies have tested the hypothesis that breast cancer patients with low-activity CYP2D6 genotypes achieve inferior benefit from tamoxifen treatment, putatively due to lack of metabolic activation to endoxifen. Studies have provided conflicting data, and meta-analyses suggest a small but significant ...

journal_title：Breast cancer research and treatment

authors： Hertz DL,Kidwell KM,Hilsenbeck SG,Oesterreich S,Osborne CK,Philips S,Chenault C,Hartmaier RJ,Skaar TC,Sikora MJ,Rae JM

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:HER2 gene is a member of the epidermal growth factor receptor (EGFR) family. Across different malignancies, aberrations of HER2 gene commonly correspond to gain-of-function alterations leading to increased receptor signaling. METHODS:We have reviewed the literature currently available on HER2 mutations in huma...

journal_title：Breast cancer research and treatment

authors： Petrelli F,Tomasello G,Barni S,Lonati V,Passalacqua R,Ghidini M

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Breast terminal duct lobular units undergo two distinctive physiological processes of involution: age-related lobular involution (LI), which is gradual and associated with decreased breast cancer risk, and postlactational involution, which is relatively precipitous, occurs with weaning, and has been associated ...

journal_title：Breast cancer research and treatment

authors： Stallings-Mann ML,Heinzen EP,Vierkant RA,Winham SJ,Hoskin TL,Denison LA,Nassar A,Hartmann LC,Visscher DW,Frost MH,Sherman ME,Degnim AC,Radisky DC

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:The utilization of staging preoperative breast MRI in biopsy-proven cancer patients varies based on institution and individual clinicians. It is unclear whether primary breast cancer subtype influences a clinician's decision to obtain a preoperative breast MRI based on likelihood of multicentric or contralatera...

journal_title：Breast cancer research and treatment

authors： Jonna AR,Sam KQ,Ebuoma LO,Sedgwick EL,Wang T,Benveniste AP

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The Z0011 trial initiated a paradigm shift in the axillary treatment of breast cancer patients with a positive sentinel lymph node biopsy (SLNB), disregarding patients with a positive ultrasound-guided lymph node biopsy (UGLNB). We examined whether relevant differences exist between these patients to determi...

journal_title：Breast cancer research and treatment

authors： Verheuvel NC,Voogd AC,Tjan-Heijnen VCG,Siesling S,Roumen RMH

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Breast density (BD), an important risk factor for breast cancer, can change over time in some women, but the underlying mechanism is unclear. Very little is known about the impact of surgical weight loss on BD. Our hypothesis is that weight loss after bariatric surgery is associated with a significant and favor...

journal_title：Breast cancer research and treatment

authors： Williams AD,So A,Synnestvedt M,Tewksbury CM,Kontos D,Hsiehm MK,Pantalone L,Conant EF,Schnall M,Dumon K,Williams N,Tchou J

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Combining molecular therapies with chemotherapy may offer an improved clinical outcome for chemoresistant tumours. Sphingosine-1-phosphate (S1P) receptor antagonist and sphingosine kinase 1 (SK1) inhibitor FTY720 (FTY) has promising anticancer properties, however, it causes systemic lymphopenia which impairs it...

journal_title：Breast cancer research and treatment

authors： Alshaker H,Wang Q,Srivats S,Chao Y,Cooper C,Pchejetski D

更新日期：2017-10-01 00:00:00